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粗粮偏好,肠道微生物群特征,与便秘患者的高甘油三血症相关:一个横截面研究
Wei Li1, Menghan Wang1, Kun Xu2
1Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
选择粗谷物而不是精制谷物可能会降低便秘患者患高甘油三血症 (HTG) 的风险. 这种饮食转变与肠道微生物群组成的有益变化有关.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 粗粒 (CG) 通过肠道微生物群对血脂产生积极影响.
- 在便秘患者中,CG偏好,血脂和肠道微生物群之间的关系尚不清楚.
研究的目的:
- 调查功能性便秘患者的粗粮偏好与血脂水平,特别是高甘油三血症 (HTG) 之间的关联.
- 探索肠道微生物群在这种关系中的作用.
主要方法:
- 16S rRNA测序和食物频率问卷被用于分析249名功能性便秘参与者的肠道微生物属和饮食习惯.
- 与精制谷物 (RG) 相比,粗粮食的偏好是由更高的摄入频率定义的.
- 机器学习模型被用来评估肠道微生物群对HTG的预测能力.
主要成果:
- 与偏好精制谷物相比,偏好粗谷物与较低的血清甘油三水平 (TG) 和降低的HTG风险有显著的关联.
- 增加CG摄入频率 (每周3次,5次或10次) 与HTG风险 (48%89%) 的大幅降低相关.
- 一个利用肠道微生物群特征的机器学习模型实现了0.79的AUC来识别HTG可能性,微生物组风险得分与CG偏好负相关 (r = -0.150,p = 0.021).
结论:
- 偏爱粗粮作为主食与功能性便秘患者患高甘油三血的风险较低有关.
- 饮食中的粗谷物摄入量会影响肠道微生物群的组成,这在管理血液脂质概况和HTG风险方面起着作用.
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