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Updated: Sep 19, 2025

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通过高通量选检测识别的KLHDC2配体进行向蛋白质降解

Han Zhou1, Tonglian Zhou1, Wenli Yu2

  • 1Department of Chemistry, Scripps Research, La Jolla, United States.

eLife
|June 16, 2025
PubMed
概括

研究人员发现了一种新的小分子,该分子向蛋白质溶解向嵌合体 (PROTACs) 的KLHDC2 E3结合酶. 这扩展了PROTAC技术,使得细胞模型中的BRD4等点蛋白质具有强大的降解能力.

关键词:
E3 结合酶的使用在KLHDC2中.这就是PROTAC.生物化学 生物化学化学生物学 化学生物学高通量选的高通量选人类 人类 人类 人类 人类 人类 人类

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