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系统性红斑狼 (SLE) 妇女的怀孕结果:来自印度的一项匹配观察研究

Prajwal Mohan¹, Kavadichanda G Chengappa², Jyotsna Sharma¹

¹Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.

International journal of rheumatic diseases

|June 16, 2025

概括

妊娠期间的全身性红斑狼 (SLE) 显著增加了高血压疾病的风险,对于妊娠年龄来说很小,以及早产. 发现氧化的使用可以减少怀孕期间和产后的狼发作.

科学领域:

产科和妇科产科和妇科
类风湿病学类风湿病学
周围生理学周围生理学

背景情况:

系统性红斑狼 (SLE) 是一种自身免疫性疾病,可以影响多个器官.
患有SLE的女性怀孕对母亲和胎儿都有独特的挑战和风险.
了解特定的胎儿-母亲结果和影响妊娠期间疾病活动的因素对于最佳管理至关重要.

研究的目的:

评估SLE与妊娠20周以后的不良胎儿-母亲结果之间的关联.
确定导致SLE妇女在怀孕期间和产后爆发狼的因素.

主要方法:

一项匹配观察性研究,将144名患有SLE的孕妇与2011-2020年期间的144名健康对照 (1:1比) 进行了比较.
评估了胎儿和母亲的结果,包括早产,高血压妊娠障碍 (HDP) 和对于妊娠年龄的小 (SGA).
使用后勤回归模型来确定SLE与结果之间的关联,以及与狼发作相关的因素.

主要成果:

患有SLE的女性的HDP (OR:5.10),SGA (OR:2.21),早产 (OR:2.61) 和围产损失 (OR:13.92) 的几率明显更高.
狼性炎和HDP与产周损失的风险增加有关 (OR:分别为4.62和9.99).
氧化使用与狼发作风险降低有关 (OR:0.15),这种风险发生在18.8%的SLE病例中.

结论:

患有SLE的孕妇面临着不良胎儿-母亲结果的高风险.
狼性炎和HDP是SLE怀孕中产周损失的重要危险因素.
基氨酸在怀孕期间和分娩后对狼发作有保护作用.

关键词:

生产性心脏阻塞是一种先天性心脏阻塞.氧化chloroquine 的使用情况新生儿狼新生儿狼怀孕怀孕怀孕怀孕怀孕系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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