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超声波无线控制的电响应植入式药物输送系统,用于增强瘤治疗

Haimei Li^1,2, Guangqin He^1,2, Yulin Hu^1,2

¹Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Small (Weinheim an der Bergstrasse, Germany)

|June 16, 2025

概括

这项研究引入了一种超声波控制的可植入药物输送系统,使用 triboelectric 纳米发电机 (TENG). 这种新型设备无线释放用于瘤切除的药物,为传统方法提供安全有效的替代方案.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

控制的局部药物输送提供了优势,而不是系统的管理.
通过外部刺激从植入式设备释放药物的无线控制是一个重大挑战.

研究的目的:

开发一种通过超声波无线控制的,电响应的植入式药物输送系统 (UI-TENG-IDDS).
为了证明该系统在药物释放和瘤切除方面的有效性.

主要方法:

一个超声驱动的植入式 triboelectric纳米发电机 (UI-TENG) 与一个电响应药物储存器相结合.
超声波刺激在UI-TENG中引起振动,产生电脉冲以电解水并溶解药物载体 (co-PMMA).
离子电泳用于增强负电荷药物的扩散.

主要成果:

在超声波应用时,UI-TENG产生脉冲电输出 (≈50μA在9V).
该系统成功地释放了甲托雷克萨特 (MTX) 和切除了瘤,副作用最小.
无线药物释放控制可以在没有复杂的电子设备或电池限制的情况下实现.

结论:

UI-TENG-IDDS提供了一种高效,经济和安全的方法,用于空间时间控制的植入式药物输送.
生物降解和生物相容材料可用于TENG制造,提高安全性.
这项技术克服了依赖电池的设备和复杂的电子设计的局限性,用于植入式药物输送.

关键词:

泰 (TengTeng) 是一个非常有价值的东西.药物输送是药物输送的过程.这是一种可植入的植入器.瘤治疗的治疗方法无线无线无线无线无线.

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