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哺乳史与循环炎症和代谢生物标志物的关系

Nan Lin¹, Allison F Vitonis¹, Jennifer M Mongiovi^1,2

¹Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

|June 16, 2025

概括

哺乳与中年期更高的胰岛素类生长因子1 (IGF1) 水平有关. 这种关联可能会影响长期的慢性疾病风险.

科学领域:

内分泌学在内分泌学.
生殖健康生殖健康
慢性疾病流行病学慢性疾病流行病学

背景情况:

哺乳史与慢性疾病风险降低有关.
连接母乳养与长期健康结果的生物学机制尚不清楚.

研究的目的:

调查母乳养史与中年生物标志物之间的关联.
探索哺乳期持续时间与炎症和代谢标志物之间的关系.

主要方法:

在护士健康研究中分析了来自16165名妇女的血样本.
测量了10个炎症和8个代谢生物标志物.
多变量调整和多次测试的FDR纠正.

主要成果:

曾经母乳养与更高的胰岛素类生长因子1 (IGF1) 水平有关.
较长的母乳养时间与较低的IL10和较高的IGF1.1相关.
在绝经前妇女中,IGF1的关联性更强;可溶性勒素受体的关联性因BMI而异.

结论:

哺乳史,特别是持续时间较长,与中年IGF1水平升高有关.
这些发现表明,母乳养对IGF1有潜在的长期系统性影响,这可能会影响慢性疾病的风险.

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