卵巢储量减少是否会影响毛囊液中的氧化降低潜力?
Minh Tam Le1,2, Nguyen Dac Nguyen1,2, Hong Nhan Thi Dang1
1Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Vietnam.
The Journal of international medical research
|June 16, 2025
概括
卵泡液中的氧化应激,以氧化降低潜力衡量,与卵子产量和卵子质量降低的女性有关,卵巢储备减少. 这一发现突显了氧化应激对生育结果的影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 氧化压力研究研究 氧化压力研究
- 在体外受精中进行体外受精.
背景情况:
- 卵巢储备 (DOR) 的减少与生育能力的降低有关.
- 氧化应激与各种生殖病理有关.
- 毛囊液氧化应激在DOR中的作用尚未完全阐明.
研究的目的:
- 用氧化降解潜力 (ORP) 评估毛囊液中的氧化应激.
- 确定毛囊液ORP与DOR患者胚胎质量之间的相关性.
主要方法:
- 在134名DOR患者和82名对照患者的横截面研究中.
- 通过通过阴道吸收收集的毛囊液.
- 使用男性不孕症氧化系统测量氧化降低潜力.
主要成果:
- 患有DOR的患者具有较低的抗米勒尔激素,卵细胞产量,胚胎细胞形成和高质量的胚胎率.
- 毛囊液ORP与卵细胞产量,成熟卵细胞率和正常受精率负相关.
- ORP与卵巢刺激的持续时间正相关.
结论:
- 毛囊液氧化应激与卵巢储备的减少有关.
- 增加的氧化应激与较少的卵细胞获取,较低的成熟卵细胞比例和正常受精率的降低相关.
- 向氧化压力可能会改善DOR患者的试管婴儿结果.
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