身体活动和癌症风险的变化,来自英国生物库研究的发现
Andrew Harper1, Christine M Friedenreich1,2,3, Momtafin Khan1
1Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Canada.
概括
中年期增加体力活动可能会降低与肥胖相关的癌症风险,特别是乳腺癌. 增加体育活动的行为改变可以帮助降低癌症风险.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 大多数体力活动和癌症风险研究使用一次性措施.
- 这项分析研究了中年身体活动变化如何影响癌症风险.
研究的目的:
- 调查中年期身体活动变化与随后的癌症风险之间的关联.
- 探索按性别和癌症类型的关联 (与肥胖相关的与非肥胖相关的,乳腺,前列腺).
主要方法:
- 英国生物库参与者 (≥40岁) 的前性队列研究,重复体力活动数据 (国际体力活动问卷).
- 身体活动的变化分为减少,维持或增加.
- 多变量考克斯回归分析以评估癌症风险关联.
主要成果:
- 身体活动变化与整体癌症风险之间没有显著的关联.
- 增加体力活动与较低的肥胖相关癌症风险相关 (HR=0.72),特别是乳腺癌 (HR=0.61).
- 女性体育活动减少与癌症风险增加有关 (HR=1.47).
结论:
- 随着时间的推移,增加身体活动与与肥胖相关的癌症,特别是乳腺癌的风险降低有关.
- 在中年期促进增加身体活动的行为干预措施可能对降低癌症风险有益.
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