慢性病风险与代谢功能障碍相关的性肝病相关:韩国一项全国性队列研究
Dong Wook Kim1, Minkook Son2,3, Hye Jung Lee4
1Division of Gastroenterology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与慢性病 (CKD) 的更高风险有关. 管理心脏代谢风险因素 (CMRFs) 对于预防MASLD患者的CKD至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,与代谢功能障碍有关.
- 心脏代谢风险因素 (CMRFs) 有助于慢性病 (CKD) 的发展.
- MASLD,CMRF和CKD之间的关系需要进一步调查.
研究的目的:
- 检查MASLD和CKD之间的关联.
- 评估CMRF对CKD风险的独立影响.
- 评估多个CMRF对CKD发展的累积影响.
主要方法:
- 使用韩国国家健康保险系统 (NHIS) 数据进行的回顾性队列研究.
- 在2009-2010年间对211,992名年龄≥40岁的个人进行查的分析.
- 分类为组:没有CMRF的脂肪性肝病 (SLD),没有CMRF的SLD,没有CMRF的SLD,MASLD和MetALD (增加酒精摄入量的MASLD).
主要成果:
- 与没有CMRF的SLD相比,MASLD与CKD风险增加1.70倍.
- 随着CMRF数量的增加,CKD风险增加,调整后的HR从1.12 (一个CMRF) 到1.97 (四个CMRF) 之间.
- 无论是MASLD还是单独的CMRF,都与CKD风险升高有关.
结论:
- 马斯尔德是CKD的独立预测因素.
- 每个CMRF都有助于CKD的发展,累积效应会放大风险.
- 早期识别和管理MASLD和CMRF对于减少CKD发病率至关重要.
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