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相关的频率和临床结果

Alexis Moscoso^1,2,3, Fiona Heeman^1,2, Sheelakumari Raghavan⁴

¹Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

|June 16, 2025

概括

在阿尔茨海默氏症 (AD) 时,定子发射断层扫描 (PET) 可以检测神经纤维纠. 阳性PET扫描在没有损伤的个体中很常见,并且在与粉样β (Aβ) PET阳性相结合时预测高临床进展风险.

科学领域:

神经成像
神经学
生物标志物发现

背景情况:

定子发射断层扫描 (PET) 可以在体内检测神经纤维状,这是阿尔茨海默病 (AD) 的关键神经病理标志.
对于阿尔茨海默病的诊断和分期,了解TAU PET阳性的频率和临床影响至关重要.

研究的目的:

在不同年龄组和临床诊断中估计PET阳性的频率.
在具有或没有认知障碍的个体中评估tau PET阳性与临床进展风险之间的关联.

主要方法:

一项纵向研究汇集了来自13个国家的21个队列的6514名参与者的数据.
参与者接受了tau PET (flortaucipir F 18) 和粉样β (Aβ) PET扫描以及临床检查.
图 PET 扫描被视觉评价为阳性,表明神经纤维状结病理 (V- VI 阶段).

主要成果:

在3487个没有认知障碍的个体中,9. 8%的tauPET阳性,阳性随年龄增长而增加.
在轻度认知障碍 (MCI) 和AD痴呆症患者中,Tau PET阳性显著更高.
在5年内,阳性AβPET和tauPET扫描的组合与进展为MCI或痴呆症的风险大大增加.

结论:

很大一部分没有认知障碍的个体呈现出阳性PET扫描.
结合Aβ PET和tau PET的阳性强烈预测了在临床前和症状AD阶段的临床进展.
PET作为一种有价值的生物标志物,用于确定阿尔茨海默病理阶段和评估临床进展风险.

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