在中年妇女中,终身创伤暴露和加速表观遗传衰老
Rebecca C Thurston1, Caroline Y Doyle1, Cynthia D J Kusters2
1Department of Psychiatry, University of Pittsburgh.
概括
终身创伤暴露与中年妇女的加速生物衰老有关. 黑人女性可能会受到更大的影响,这表明在创伤中存在潜在的种族差异.
科学领域:
- 表观遗传学和衰老研究研究.
- 妇女健康研究 妇女健康研究
- 创伤和健康结果
背景情况:
- 创伤暴露是加速生物衰老的潜在贡献者.
- 以前的研究主要集中在童年虐待,对终身创伤的数据有限,特别是在女性身上.
- 新兴的表观遗传钟提供了与健康结果的增强联系,需要在创伤研究中对其进行调查.
研究的目的:
- 通过使用多个表观遗传时钟,研究中年女性一生创伤暴露与表观遗传年龄之间的关联.
- 探索童年虐待与表观遗传年龄之间的关系.
- 检查创伤和表观遗传年龄之间的关系中的潜在种族差异.
主要方法:
- 该研究包括216名中年女性 (平均年龄59岁),其中一小部分也被评估为童年虐待.
- 终身创伤暴露和童年虐待通过问卷进行了测量.
- 表观遗传年龄是使用外部表观遗传年龄,GrimAge,PhenoAge和DunedinPACE计算的,分析对共变量进行了调整,并测试了种族相互作用.
主要成果:
- 经历过两次或多次生命创伤的女性表现出显著更大的表观遗传年龄 (GrimAge和DunedinPACE).
- 童年性虐待独立地与较大的表观遗传年龄 (GrimAge) 有关.
- 探索性分析表明,创伤与表观遗传年龄的关联在黑人女性中更为明显.
结论:
- 增加终身创伤暴露,以及潜在的童年性虐待,与中年女性的表观遗传衰老加速有关,而不依赖于时间年龄.
- 研究结果表明,黑人女性可能会受到创伤和生物衰老之间的关系的不成比例的影响.
- 这项研究强调了考虑终身创伤和利用先进的表观遗传标记在衰老研究中的重要性,特别是在多样化的人口中.
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