雌激素缺乏对肝脏代谢的影响;对激素替代疗法的影响
Jiawen Dong1, Kaitlyn M J H Dennis1, Radha Venkatakrishnan2
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
Endocrine reviews
|June 16, 2025
概括
由于雌激素缺乏,与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著影响绝经后妇女. 激素替代疗法 (HRT) 可能在这个人口群体中为MASLD提供一种潜在的治疗策略.
科学领域:
- 肝病学和内分泌学.
- 妇女健康 妇女健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍存在的全球性肝病,具有显著的死亡风险.
- MASLD表现出性二态,在绝经后妇女中患病率和严重程度增加,与雌激素缺乏有关.
- 雌激素缺乏会加剧多系统代谢功能障碍,包括肝脏脂质积累,胰岛素抵抗和纤维化.
研究的目的:
- 审查女性中MASLD的负担.
- 检查雌激素缺乏在MASLD发展和进展中的作用.
- 探索在绝经后妇女中针对MASLD的潜在性别特异性治疗策略.
主要方法:
- 文献综述侧重于MASLD,雌激素缺乏症和更年期荷尔蒙替代疗法 (HRT).
- 对雌激素在代谢功能障碍中的作用的临床前数据的分析.
- 讨论当前的治疗缺口和未来的研究方向.
主要成果:
- 雌激素缺乏与肝脏脂质积累,胰岛素耐药性和MASLD特征纤维化有关.
- 临床前证据表明雌激素会影响脂肪和骨肌肉中的肝外代谢过程.
- 尽管HRT使用量增加,但HRT对绝经后妇女的MASLD的影响仍未得到充分研究.
结论:
- MASLD对绝经后妇女来说是一个重大的健康挑战.
- 雌激素在缓解MASLD背后的代谢功能障碍方面发挥着至关重要的作用.
- HRT为绝经后妇女的MASLD管理提供了一个潜在的,但尚未被充分探索的治疗途径.
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