缺氧诱导因子1对炼的人类骨肌肉中血管内皮生长因子表达的影响:系统性审查和元分析
Jerónimo Aragón-Vela1, Rafael A Casuso2
1Department of Physiology, Universidad de Jaén, Jaén, Spain.
American journal of physiology. Cell physiology
|June 16, 2025
概括
缺氧诱导因子1α (HIF-1α) 在运动后的骨肌肉中升高. 然而,HIF-1α水平与血管内皮生长因子 (VEGF) 表达不相关,这表明其在运动诱导血管生成中的作用尚不清楚.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 骨肌肉生物学 骨肌肉生物学
背景情况:
- 收缩的骨肌体验氧气减少,激活缺氧诱导因子1α (HIF-1α).
- HIF-1α信号与血管内皮生长因子 (VEGF) 和骨肌血管生成有关.
- 在肌中运动诱导的VEGF表达中,HIF-1α的确切作用尚未完全理解.
研究的目的:
- 系统地审查和综合有关HIF-1α激活在炼的人类骨肌肉的证据.
- 为了研究HIF-1α和运动后VEGF表达之间的关系.
- 为了澄清HIF-1α在运动诱导的血管新生反应中的作用.
主要方法:
- 系统的文献综述和21项研究的元分析.
- 从235个受试者的HIF-1α和VEGFmRNA数据的定量合成.
- 进行元回归分析,以评估HIF-1α和VEGF之间的关系.
主要成果:
- 在高强度和阻力运动后,HIF-1α mRNA显著增加,无论身体健康水平如何.
- 在运动诱导的HIF-1α mRNA水平和VEGF mRNA表达之间没有发现显著的关系.
- 超回归表明,VEGF表达不受HIF-1αmRNA水平的调节.
结论:
- 在运动后收缩的骨肌肉中表达HIF-1α.
- 目前的证据不支持HIF-1α mRNA在运动诱导的VEGF表达中的直接调节作用.
- 需要进一步的研究,特别是关于翻译后调节的研究,以阐明HIF-1α在骨肌肉血管生成中的作用.
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