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Updated: Sep 19, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

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针对癌细胞中非编码RNA之间的合成致命相互作用的双CRISPR干扰策略

Jeffrey L Schloßhauer1, Sama Shamloo1, Katja Schamrin1

  • 1Chemical Genomics Centre of the Max Planck Society; Max Planck Institute of Molecular Physiology.

Journal of visualized experiments : JoVE
|June 16, 2025
PubMed
概括

这项研究引入了一种双CRISPR干扰 (CRISPRi) 系统,用于精确准黑色素瘤中的长非编码RNA (lncRNAs). 这种新的工具可以选对癌细胞存活至关重要的 lncRNA 相互作用,为新的癌症疗法铺平了道路.

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