预防脑的呼吸系统疾病:试点随机对照试验的结果
Ryan J Coller1, Kristina Singh-Verdeflor1, Jens Eickhoff2
1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
RE-PACT干预是可行的,可接受的,以预防严重脑 (CP) 的儿童的呼吸系统疾病. 这种方法显示,与通常护理相比,严重呼吸道疾病事件的发生率降低了.
科学领域:
- 儿科肺病学 儿科肺病学
- 神经学 神经学
- 临床干预研究 临床干预研究
背景情况:
- 呼吸系统疾病是严重脑 (CP) 的儿童死亡和住院的主要原因.
- RE-PACT (呼吸道恶化 - 行动计划和护理过渡) 的干预旨在预防这一群体的呼吸道疾病.
- RE-PACT将早期疾病检测与快速临床反应相结合,以主动管理呼吸系统问题.
研究的目的:
- 为了确定RE-PACT干预的可行性,可接受性和忠实性.
- 为了估计RE-PACT对严重呼吸道疾病 (SRI) 事件的影响大小.
- 收集数据,为未来的RE-PACT疗效测试提供信息.
主要方法:
- 一个两站点随机对照试验 (RCT) 涉及严重CP (GMFCS 4-5级) 和呼吸需求的儿童.
- 参与者被随机分配到通常的护理或RE-PACT干预六个月.
- 主要结局包括可行性,可接受性和忠实性; 主要临床结局是SRI事件率 (呼吸道诊断住院).
主要成果:
- RE-PACT干预表明了可行性,可接受性和高准确性 (97.5%的短信响应率).
- 系统可用性得分被评为"良好至优秀" (平均79.5).
- 与常规护理组相比,RE-PACT组的SRI事件发生率较低 (0.71人/年),风险比率为0.66.6,与常规护理组相比 (1.08人/年).
结论:
- 对于患有严重脑膜炎的儿童的家庭来说,RE-PACT是一个可行的和可以接受的干预措施.
- 在不同的家庭环境中实现了RE-PACT的高保真性交付.
- 这些发现支持对RE-PACT进行进一步的疗效测试,以预防严重肺炎儿童的严重呼吸系统疾病.
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