韩国-多元环境风险评分与精神分裂症谱系障碍的临床结果之间的关联
Ariana Setiani1,2, Ling Li1,2, Thi Hung Le1,2
1Department of Psychiatry, Jeonbuk National University Medical School, Jeonju 54907, Republic of Korea.
Schizophrenia bulletin
|June 16, 2025
概括
韩国多环境风险评分 (K-PERS) 有效地将精神分裂症谱系障碍 (SSD) 与健康个体区分开来,并预测临床结果. 这种环境风险评分与患者的症状严重程度和功能有关.
科学领域:
- 精神病学是一个精神病学.
- 环境流行病学环境流行病学
- 临床心理学 临床心理学
背景情况:
- 环境因素越来越多地被认为对精神病发展和疾病预后的作用.
- 韩国 - 多国环境风险评分 (K-PERS) 是为了量化累积环境风险暴露而开发的.
- 它在区分精神分裂症谱系障碍 (SSD) 和其临床关联方面的实用性需要进一步调查.
研究的目的:
- 评估K-PERS在确定SSD患者与健康对照者 (HCs) 相比的辨别有效性.
- 检查K-PERS得分与SSD患者的基线临床特征之间的关联.
- 评估K-PERS对短期临床结果的预测价值,包括治疗反应,缓解和恢复.
主要方法:
- 韩国早期精神病研究队列提供了224名SSD患者和203名匹配的HC的数据.
- 参与者使用K-PERS,积极和消极综合症量表 (PANSS),前性和回顾性记忆问卷 (PRMQ) 以及社会和职业功能评估量表 (SOFAS) 来进行评估.
- 临床评估和K-PERS评估在基线和注册后的2,6和12个月进行.
主要成果:
- K-PERS-I和K-PERS-II显示出良好的区分性能,其AUC分别为0.738和0.754.
- 较高的K-PERS得分与更大的症状严重程度 (抑郁症,负面症状),较差的认知功能 (PRMQ) 和社会职业功能 (SOFAS) 的降低显著相关.
- 特定的K-PERS组件和总得分预测了SSD患者的治疗反应,缓解和恢复.
结论:
- K-PERS显示出强大的区分能力,用于在一般人群中识别SSD.
- K-PERS与关键临床指标有显著的相关性,包括症状严重程度,认知缺陷和社会职业障碍.
- 该K-PERS作为一种有价值的工具,以了解环境因素对精神分裂症谱系障碍的过程和结果的影响.
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