相关实验视频

Updated: Sep 19, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.4K

用MG53治疗改善了创伤性脑损伤相关的急性损伤

Marjorie R Liggett1, Bowen Wang, Zaiba S Dawood

  • 1From the Department of Surgery (M.R.L., B.W., Z.S.D., G.J., J.W.H., M.E.T., B.L., D.C.C., A.S., H.B.A.), Feinberg School of Medicine, Northwestern University, Chicago; Department of Pathology (M.Z.), University of Chicago, Chicago; Proteomics Center of Excellence (V.W., I.P., A.S., M.C., N.L.K.), Northwestern University, Evanston; Department of Medicine, Division of Hematology Oncology (M.C.), Feinberg School of Medicine, Northwestern University, Chicago; Departments of Molecular Biosciences (N.L.K.), Chemistry (N.L.K.), and Chemical and Biological Engineering (N.L.K.), Northwestern University, Evanston; Department of Biochemistry and Molecular Genetics (N.L.K.), Feinberg School of Medicine, Northwestern University, Chicago; and Department of Surgery (Y.Y., K.H.P., J.M.), University of Virginia School of Medicine, Charlottesville, Virginia.

The journal of trauma and acute care surgery
|June 16, 2025
PubMed
概括

创伤性脑损伤 (TBI) 可以导致器官损伤. 在大型动物模型中,MG53蛋白疗法保护脏免受TBI诱导的急性损伤,这表明多器官功能障碍的潜在治疗方法.

关键词:
创伤性脑损伤是一种创伤性脑损伤.急性脏损伤急性脏损伤脑内皮质变异症 (Endotheliopathy) 是一种内皮质变异症.多器官功能障碍多器官功能障碍猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

更多相关视频

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.8K

相关概念视频

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
52
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
83
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
105
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
101
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
69