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对于超极化[1-¹³C]pyruvate MRI 多中心人体研究的共识建议

Shonit Punwani^1,2, Peder E Z Larson³, Christoffer Laustsen⁴

¹Department of Radiology, University College London Hospital NHS Foundation Trust, London, UK.

Magnetic resonance in medicine

|June 16, 2025

概括

在多中心超极化 (HP) [1-¹³C]pyruvate MRI研究的最佳实践上达成共识. 这推动了这种体内代谢评估技术的临床应用.

科学领域:

医疗成像医学成像
生物物理学的生物物理.
代谢研究研究代谢研究

背景情况:

超极化 (HP) [1-¹³C]pyruvate MRI 能够在体内评估细胞代谢.
这种技术已被转化为在多个国际中心跨越各种疾病的人类研究.

研究的目的:

建立关于使用HP [1-¹³C]pyruvate MRI进行多中心人体研究的最佳实践的共识.
引导该成像模式的临床应用程序的开发和标准化.

主要方法:

一场两轮正式的共识建设演习,涉及来自13个地点的29名专家.
专家代表了药房方法,MRI物理,翻译成像和数据分析.
评估了246份涵盖准备,系统设置,采购,重建和数据分析的陈述.

主要成果:

在所有评估类别中,大约三分之二的陈述达成了共识.
关键的协议包括HP酸盐制剂的标准化释放标准和现场资格的基于幻影的质量保证.
针对特定的脉冲序列和基于解剖学目标的重建方法,以及作为首选指标的正常化代谢物面积-曲线下值的偏好.

结论:

HP [1-¹³C]酸MRI技术已经足够成熟,可以计划多中心研究.
协商一致过程确定了多中心研究的共识领域,并突出了需要进一步研究的领域,以确定最佳最佳实践.

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