在肺高血压协会注册表中,环境空气污染暴露和死亡率
Xinmei Huang1, Aparna Balasubramanian2, Jude Moutchia3
1Department of Environmental and Occupational Health Sciences, School of Public Health.
长期暴露于细颗粒物 (PM2.5) 空气污染与肺动脉高血压 (PAH) 或慢性血栓栓塞性肺高血压 (CTEPH) 患者的生存结果没有显著联系. 需要进一步的研究来探索影响这种关系的区域因素.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 肺部医学 肺部医学
背景情况:
- 环境空气污染对肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 存活率的长期影响尚不清楚.
- 颗粒物 (PM2.5),二氧化 (NO2) 和臭氧 (O3) 是常见的空气污染物,具有潜在的健康影响.
研究的目的:
- 调查PM2.5,NO2和O3暴露与肺高血压协会注册表 (PHAR) 中患者的死亡率或肺移植风险之间的关联.
主要方法:
- 利用了2,196名成年PHAR患者 (2015-2024) 的数据.
- 从时空模型到患者住所的年平均空气污染物度 (PM2.5,NO2,O3) 的联系.
- 采用了考克斯的比例危险模型,调整了人口统计,社会经济因素,疾病严重程度和空间混因素.
主要成果:
- 在初始模型中,PM2.5暴露显示出增加死亡率或肺移植风险的趋势 (HR 1.16每IQR增加),但在空间共变量调整 (HR 1.12) 后,这在统计学上并不显著.
- 在NO2或O3暴露和生存结果之间没有发现显著的关联.
- 观察到PM2.5协会的区域差异,表明局部影响.
结论:
- 在PHAR队列中,长期暴露于环境空气污染与PAH或CTEPH患者的存活率没有显著关联.
- 未来的研究应该探讨在这些条件下,区域社会决定因素和医疗保健因素如何改变空气污染与死亡率的关系.
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