与代谢功能障碍相关的脂肪性肝病和肉症之间的关系:系统性审查和元分析
Ninglin Xia1, Jiwei Wang1, Qian Lu1
1New Drug Screening and Pharmacodynamics Evaluation Center, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Clinical nutrition ESPEN
|June 16, 2025
概括
皮症显著增加了患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险. 在MASLD患者中早期发现肉类是预防晚期肝病和死亡的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肉类是全球普遍存在的疾病.
- 了解这些条件之间的相互作用对于公共卫生至关重要.
研究的目的:
- 量化萨科佩尼亚诊断与患MASLD的风险之间的关联.
- 调查萨科佩尼亚对MASLD进展和患者结局的影响.
主要方法:
- 在主要数据库 (Web of Science,PubMed,Embase,OVID) 进行了系统的文献审查.
- 将研究纳入到2024年3月10日,以确定有关肉症和MASLD的相关研究.
- 分析了63项涉及288,583名参与者的研究数据.
主要成果:
- 萨科佩尼亚与37%的MASLD风险增加有关 (OR: 1.37).
- 麻症的MASLD患者表现出较低的骨肌肉指数 (SMI) 和步行速度.
- 降低SMI和肌肉强度与更高的MASLD风险相关,而MASLD患者的肉症增加了肝纤维化,死亡率和全因死亡率的风险.
结论:
- 患有肉类的个体面临着更高的MASLD风险.
- 低SMI和肌肉强度与MASLD发生率增加有关.
- 在MASLD患者中,sarcopenia增加了晚期肝病,肝纤维化和死亡的风险,需要临床警.
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