快速UV诱导和坚固的甲化丝纤维蛋白增强的基于聚烯胺的三重交联水凝
Mili Tilieke1, Xiong Shu2, Lei Chen2
1International Research Center for Advanced Structural and Biomaterials, School of Materials Science & Engineering, Beihang University, Beijing 100191, People's Republic of China.
International journal of biological macromolecules
|June 16, 2025
概括
这项研究通过将丝纤维素纳入聚烯胺中来开发出一种强大,耐用的软骨替代水凝. 由此产生的材料显示出出色的机械性能和生物相容性,用于组织再生.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 开发用于软骨置换的耐用水凝具有挑战性.
- 甲基化丝纤维素 (SFMA) 和聚烯胺 (PAM) 水凝有希望,但缺乏足够的强度.
- 纯SFMA或PAM水凝对于体内结构应用是不够的.
研究的目的:
- 为了创建一个强大的和生物相容的水凝用于软骨修复.
- 使用丝纤维素增强聚烯胺基水凝的机械性能.
- 调查SFMA修改对水凝性能和生物相容性的影响.
主要方法:
- 在10秒内以SFMA修饰的聚烯胺 (SFMA-AM) 水凝的in situ紫外线聚合.
- 通过乙醇处理加强SFMA-AM水凝 (SFMA-AM ET),以增强物理网络相互作用.
- 机械测试 (压力强度,模量,疲劳阻力).
- 在体外细胞相容性测定和体内皮下植入.
主要成果:
- 由于共价和疏水相互作用,SFMA-AM水凝表现出极好的弹性和强度.
- SFMA-AM ET水凝达到4.4MPa的压力强度和580kPa的模量.
- SFMA-AM ET水凝表现出优越的疲劳耐力 (>800个周期) 没有失败.
- 这两种水凝类型都显示出出色的生物相容性,促进细胞增殖和组织再生.
结论:
- 将SFMA纳入PAM显著改善了水凝的机械性能和生物相容性.
- 该SFMA修改策略提供了一种多功能方法来增强传统的烯酸胺基水凝.
- 这些先进的水凝具有广泛的生物医学应用潜力,包括软骨置换和组织再生.
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