巨细胞在自闭症谱系障碍中的作用
Laura Priego-González1, Paula Perez Pardo1, Frank Redegeld1
1Division of Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Neuroscience and biobehavioral reviews
|June 16, 2025
概括
乳腺细胞 (MCs),免疫细胞参与炎症,可能在自闭症谱系障碍 (ASD) 的发展中发挥作用. 针对MCs为ASD提供了潜在的新治疗策略.
科学领域:
- 神经免疫学 神经免疫学
- 胃肠病学 胃肠病学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其原因尚不清楚,并且没有确定的治疗方法.
- 免疫失调越来越被认为是ASD病理生理学的因素.
- 已知过敏反应的母细胞 (MCs) 涉及到更广泛的免疫和炎症过程.
研究的目的:
- 探索将乳腺腺细胞 (MCs) 与自闭症谱系障碍 (ASD) 联系起来的潜在机制.
- 审查MCs在神经炎症,自身免疫和ASD中的肠-大脑轴中的作用.
- 讨论针对ASD的MC向治疗方法.
主要方法:
- 关于巨细胞和自闭症谱系障碍研究的文献综述.
- 分析证据,将巨细胞媒介与ASD中神经炎症联系起来.
- 检查巨细胞参与自身免疫和与ASD相关的肠-大脑轴干扰的参与.
主要成果:
- 巨细胞介质 (希斯胺,血清素,细胞因子) 影响ASD中改变的神经炎症通路.
- 脑细胞与免疫和神经细胞相互作用,可能导致ASD症状.
- 通过肠道透性和微生物群的改变,MCs可能会导致自免疫和ASD中常见的胃肠道并发症.
结论:
- 乳腺细胞与自闭症谱系障碍的关键病理生理过程有关,包括神经炎症,自身免疫力和肠-大脑轴功能障碍.
- 向巨细胞活动为ASD干预提供了一个有希望的治疗途径.
- 对免疫介导机制的进一步研究为新的ASD治疗策略提供了潜力.
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