结核病和加密球菌共同感染的全球评估:系统性审查
Sareh Bagheri-Josheghani1, Zahra Rafat2, Parivash Davoodian3
1Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Microbial pathogenesis
|June 16, 2025
概括
结核病 (TB) 和密码球菌病的同时感染显著增加了死亡率. 识别艾滋病毒等危险因素和了解治疗,如组合抗真菌疗法,对于更好的患者结果至关重要.
科学领域:
- * 传染病 传染病
- * 免疫学 免疫学
- * * 公共卫生 公共卫生
背景情况:
- *结核病 (TB) 和密码球菌病的同时感染是由于细胞介导免疫力受损而带来的重大临床挑战.
- *这种双重感染与高死亡率和发病率有关,需要对其流行病学和管理有更深入的了解.
- *有效的早期诊断,预防和治疗策略对于改善患者的治疗结果至关重要.
研究的目的:
- *系统地审查和综合有关结核病和密码球菌病共感染患者的风险因素,诊断方法和治疗方法的当前知识.
- * 提供有价值的见解,可以促进快速诊断,有效预防和及时治疗这种共感染.
- * 确定关键的流行病学趋势和与密码球菌和结核病联合感染相关的流行病态.
主要方法:
- * 在主要的电子数据库 (谷歌学者,Scopus,PubMed,科学网) 进行了全面和系统的文献搜索.
- *搜索涵盖了2000年1月至2023年12月以英语出版的文章,遵守PRISMA指南.
- *总共有47项相关研究,包括68名同时感染患者的数据,被纳入最终分析.
主要成果:
- *印度报告的同时感染患者数量最高 (38.23%).
- *人类免疫缺陷病毒 (HIV) 感染是最常见的潜在疾病 (31.35%).
- *用安福特瑞辛B和可纳 (63.23%) 进行的联合治疗是最常见的抗真菌治疗方法,而利法素 (38.23%) 则经常用于结核病治疗.
结论:
- * 流行病学数据对于早期诊断和迅速治疗结核病-密码球菌联合感染至关重要.
- *了解流行风险因素,特别是艾滋病毒,是针对性预防和管理策略的关键.
- *目前的治疗主要涉及结合抗真菌疗法和标准抗结核药物,突出需要优化治疗方案.
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