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在头部和部放射治疗后,基于成像的上部变化:系统性审查和元分析
Vitoria Tavares Castro1, Larissa Di Carvalho Melo1, Yuri Silvestre-Barbosa1
1University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences, Brasília, Brazil.
Journal of stomatology, oral and maxillofacial surgery
|June 16, 2025
概括
头癌 (HNC) 的放射治疗会导致关节骨的显著变化,包括骨质放射性死 (ORN). 先进的成像对于早期检测和管理这些辐射诱导的骨并发症至关重要.
科学领域:
- 口腔和面放射学 口腔和面放射学
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 接受放射治疗的头癌 (HNC) 患者通常会对骨完整性产生不良影响.
- 了解这些上关骨变化对于患者管理和治疗计划至关重要.
研究的目的:
- 在HNC患者进行放射治疗后,系统地审查和评估上关骨变化.
- 综合从定性和定量成像分析的发现.
主要方法:
- 按照PRISMA指南进行系统审查,使用PEOS框架.
- 在主要数据库 (PubMed,Embase,Cochrane,Web of Science) 和灰色文献中进行全面的文献搜索.
- 包括观察性研究和实验性临床试验;排除高风险偏差研究.
主要成果:
- 包括30项涉及2441名患者的研究,报告了骨质整体变化,如骨质放射性缩 (ORN,7%),骨硬化和骨密度下降.
- 全景放射是常见的;定量分析 (放射学,碎形维度) 检测到微妙的骨质恶化.
- 还注意到牙周变化和骨愈合受损 (延迟骨化,非结合).
结论:
- 放射治疗显著影响头癌患者的骨完整性和愈合能力.
- 先进的成像技术对于早期检测辐射引起的骨并发症至关重要.
- 需要个性化干预来减轻这些不良影响.
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