在肥胖和心脏代谢健康中含有histidine的dipeptides:一个系统的范围审查
Saeede Saadati1,2, Robel Hussen Kabthymer2, Giancarlo Aldini3
1Monash Centre for Health Research and Implementation (MCHRI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
概括
含有歇斯蒂丁的二 (HCDs) 在控制2型糖尿病 (T2D) 风险因素和并发症方面表现有前途. 需要进一步的人类研究来证实对心脏代谢健康的益处.
科学领域:
- 营养生物化学 营养生物化学
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
背景情况:
- 含有西丁的二 (HCDs) 具有抗炎和抗糖尿病的特性.
- 关于HCDs对2型糖尿病 (T2D) 风险因素如肥胖和并发症的影响的审查有限.
- 肉是研究最多的HCD,对心脏代谢健康有潜在的益处.
研究的目的:
- 进行范围审查,检查HCD对T2D风险因素和并发症的影响.
- 研究HCDs的作用机制,特别是肉素.
- 综合实验,观察和随机对照试验 (RCT) 研究的证据.
主要方法:
- 在多个数据库 (Ovid-Medline,Embase,CINAHL,Scopus,Web of Science,Cochrane Library) 进行系统的文献搜索,直到2023年12月.
- 包括实验 (动物/细胞),观察和RCT研究.
- 专注于肥胖和/或T2D患者的HCD影响.
主要成果:
- 包括121项研究,揭示HCD可以减轻炎症,改善脂质概况和肥胖和T2D的血糖控制.
- 大多数证据来自探索机制的实验研究;存在有限的观测数据和RCT.
- 没有任何RCT专门研究HCD对糖尿病神经病变,视网膜病变,脑血管或心血管疾病的影响.
结论:
- 临床前证据通常支持HCDs改善心脏代谢健康.
- 需要进一步的人类研究,特别是大型RCT,以验证这些发现.
- HCD在治疗T2D并发症方面的潜力需要更严格的调查.
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