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贝水提取物 通过PI3K/AKT/Bcl-2通路在老鼠中缓解甲引起的肠
Hongyi Zhang1, Qiaoling Ma1, Weichao Wang1
1State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
NPJ science of food
|June 16, 2025
概括
贝取物显示出对甲状腺健康的潜力. 高剂量提取物改善了甲状腺激素水平,并在研究中减少了,这表明贝可能是功能性食物来源.
科学领域:
- 海洋生物学 海洋生物学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 贝通常被认为是废物,造成资源效率低下的问题.
- 这项研究探讨了贝在健康应用中的未充分利用的潜力.
研究的目的:
- 为了研究贝水提取物 (WE) 的化学成分和药理活性.
- 为了评估贝 WE 分数的抗喉潜力.
主要方法:
- 贝WE被分成外膜 (WEE) 和内膜 (WEI) 组件.
- 用UPLC-Q-ExactiveMS识别了组件;通过ELISA,网络药理学,RT-qPCR和西式涂抹评估了药理活性.
主要成果:
- 在WE中发现了231个成分,包括有机酸和氨基酸.
- 高剂量的WEE显著调节了甲状腺激素 (T3,T4,FT3,FT4,TSH) 并改善了甲状腺病变.
- 通过抑制PI3K/AKT/Bcl-2通路,WEE显示出抗口腔炎的作用.
结论:
- 贝水提取物具有显著的抗喉特性.
- 这些发现为开发贝成为功能性食品成分提供了科学基础.
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