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Updated: Sep 19, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

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通过psilocybin预防自杀的分子机制:来自网络药理学和分子对接分析的证据

Ying Zhang1,2, Lei Yang1,2, Qiuyu Zhang1,2

  • 1Laboratory of Computational Biology and Computational Psychiatry (CBCP-Lab), Tianjin Anding Hospital, Nankai University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Mental Health Center, Tianjin, 300222, China.

Translational psychiatry
|June 16, 2025
PubMed
概括

这项研究探讨了psilocybin如何使用网络药理学和分子对接来帮助预防自杀. 确定了像HTR2A这样的关键目标,这表明调节了血清突触和信号通路.

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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