孕产妇的微量元素暴露在怀孕早期对孕产妇甲状腺激素和出生结果的影响
Ting Wu1,2, Tao Li1,2, Chen Zhang3
1The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200030, China.
Biological trace element research
|June 16, 2025
概括
在怀孕早期,母亲暴露于 (Cr) 等微量元素会影响甲状腺激素和胎儿生长. 增加的Cr暴露与婴儿出生长度和头周长的增加有关,突出了潜在的风险和需要安全门的需要.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 围产期流行病学 围产期流行病学
背景情况:
- 关于微量元素对母亲甲状腺激素和分娩结果的影响的证据有限.
- 众所周知,重金属有助于不利的健康结果.
- 了解产前微量元素的暴露对于母婴健康至关重要.
研究的目的:
- 调查第一季度暴露于七种微量元素对母亲甲状腺激素和分娩结果的影响.
- 确定特定元素及其对观察到的协会的贡献.
- 探索剂量反应关系和潜在的非线性影响.
主要方法:
- 在中国上海进行的前性队列研究,包括1351名孕妇.
- 对七种微量元素的分析: (V), (Cr), (Mn), (Co), (Ni), (As) 和 (Se).
- 统计方法包括线性回归,受限立方线 (RCS) 和定量g计算 (QGC).
主要成果:
- 母亲接触元素混合物与增加的三甲基氨酸 (TT3) 和婴儿出生时间的增加有关,主要是由 (Cr) 驱动的.
- 较高的Cr度与较大的婴儿出生长度和头周长相关.
- (Se) 和 (As) 暴露与分别增加婴儿头周和甲状腺刺激激素 (TSH) 水平有关.
- 在 (As), (Cr) 和自由三铁 (FT3) 之间,以及在 (V) 和TT3.3之间观察到U形关系.
结论:
- 孕妇在怀孕早期接触微量元素混合物会改变甲状腺激素并加速胎儿的生长,其中 (Cr) 是一个关键的贡献者.
- 某些元素 (V,Cr,As) 与母亲的甲状腺激素之间的非线性U形关联表明了复杂的生物相互作用.
- 这些发现凸显了为产前微量元素暴露建立双相临床安全值的必要性.
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