与重金属的职业污染物相关的健康风险跨越不同的职业
Sosan Andleeb Khan1, Syed Muhammad Nurulain2,3, Baseet Haroon Khan4
1Biotechnology/Microbiology Department, University of Poonch, Rawalakot, Pakistan.
Environmental geochemistry and health
|June 16, 2025
概括
长期暴露于工作场所的重金属如 (Pb) 对巴基斯坦工人的健康产生负面影响,影响肝脏,脏和胰腺功能. 即使是低水平的暴露也会带来风险,这凸显了发展中国家安全措施的不足.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 毒理学 毒理学 毒理学
背景情况:
- 工作场所污染物,特别是重金属,即使在低度下,也会造成慢性健康风险.
- 职业接触重金属是发展中国家的重大问题,这些国家的安全法规不足.
研究的目的:
- 在巴基斯坦的各种职业群体中调查慢性重金属暴露对健康的影响.
- 评估特定重金属 (Mn,Ni,Co,Cu,Pb) 对脏,肝脏,胰腺和脂质参数的影响.
主要方法:
- 一项涉及404名长期暴露个体和来自七个职业群体的170名对照者的病例控制研究.
- 使用感应合等离子体质谱法 (ICP-MS) 进行重金属分析.
- 生物化学参数的评估 (肝脏,脏,胰腺,脂质配置文件) 使用标准色度和酶技术.
主要成果:
- 在暴露的工人中检测到高水平的 (Mn), (Ni), (Co),铜 (Cu) 和 (Pb).
- 在肝脏标志物 (ALT,AST,ALP,LDH,GGT),功能测试 (BUN,肌素),胰腺参数 (胰岛素,葡萄糖,氨酶,脂酶,HOMA-IR) 和脂质资料中观察到显著的失调.
- (Pb) 暴露与多器官毒性特别相关.
结论:
- 持续接触重金属混合物对巴基斯坦职业群体的健康构成重大风险.
- 在非金属暴露的工人中,微量重金属的存在表明广泛的污染和不充分的安全协议.
- 发展中国家迫切需要改善工作场所安全措施,以减轻重金属相关的健康问题.
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