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热中风和热疲劳的诊断生物标志物:一个范围审查
Joanna Palasz1, Walid Farooqi1, Muhammad Bazil Musharraf2
1Department of Emergency Medicine, https://ror.org/02r109517Weill Cornell Medicine, New York, NY, USA.
Disaster medicine and public health preparedness
|June 16, 2025
概括
气候变化增加了与热量相关的疾病,需要更好的诊断工具. 这次审查发现了许多潜在的生物标志物,但由于研究方法的多样性,没有一个生物标志物准备好临床使用.
科学领域:
- 环境健康 环境健康
- 临床诊断 临床诊断 临床诊断
- 生物标志物研究 生物标志物研究
背景情况:
- 由于气候变化和热浪,全球热相关疾病的发生率正在上升.
- 可靠的诊断工具对于在临床环境中管理与热有关的疾病至关重要.
研究的目的:
- 系统地审查和总结关于用于诊断与热有关的疾病的生物标志物的已发表证据.
- 确定潜在的诊断生物标志物用于临床应用.
主要方法:
- 在Embase,MEDLINE和Cochrane图书馆进行了全面的文献搜索 (2022年10月 - 2024年1月).
- 手动参考列表搜索包含的文章.
- 研究的详细总结与统计验证.
主要成果:
- 发现了2877个引用;审查了228个全文研究. 56%来自中国或北美.
- 确定了113种不同的生物标志物,其中素I,IL-6,血小板和ALT是最常见的.
- 在研究方法和生物标志物验证方面观察到显著的异质性.
结论:
- 已经研究了许多生物标志物,但没有一个证明了临床效用.
- 方法和统计验证的不一致性阻碍了生物标志物的应用.
- 需要进一步的研究来确定与热有关的疾病的临床相关和验证的生物标志物.
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