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68 Ga-FAPI-04 PET在患有18 F-FDG-Avid结肠损伤的患者中区分良性和恶性

Na Qi¹, Haiyan Wang, Jie Ding

¹Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Clinical nuclear medicine

|June 17, 2025

概括

在结直肠PET扫描中强烈的18F-FDG吸收可以表明良性或恶性病变. 纤维细胞激活蛋白抑制剂 (FAPI) PET可能有助于在手术前区分结直肠癌和腺瘤.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

使用18F-FDG的正子发射断层扫描 (PET) 对于检测结直肠病变至关重要.
在良性和恶性结直肠疾病中可以观察到高的18F-FDG吸收,需要进一步的诊断评估.
在手术前区分结直肠腺瘤和癌瘤仍然是一个临床挑战.

研究的目的:

报告一个有强烈18F-FDG吸收但68Ga-FAPI-04 PET吸收为负的西格结肠管状腺瘤病例.
突出FAPI PET在区分结直肠腺瘤和癌症中的潜在作用.

主要方法:

一名65岁的男性患者接受了PET扫描.
患者在18F-FDG PET.上表现出强烈的吸收.
患者在68Ga-FAPI-04 PET上显示了负吸收.

主要成果:

这名患者被诊断为西格肠管状腺瘤.
管状腺瘤表现出强烈的18F-FDG吸收.
同一个病变显示了负的68Ga-FAPI-04 PET吸收.

结论:

这一案例表明,FAPI PET可能是手术前分化结直肠病变的一个有价值的工具.
在高18F-FDG吸收的情况下,负面的FAPI PET吸收可能表明良性腺瘤超过癌症.
FAPI PET成像可能会影响结直肠病变的手术和治疗策略.

关键词:

聚乙烯/聚乙烯/聚乙烯聚乙烯 (PET) /MR (MR) 是一种腺瘤腺瘤是一种

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