回归和非回归自闭症的比较分析:土耳其临床模式和环境风险因素的研究
Nagihan Cevher Binici1, Ayşe Kutlu2, Çisel Yazan Songür3
1Department of Child and Adolescent Psychiatry, Behçet Uz Children's Hospital, University of Health Sciences, Izmir, Turkey.
International journal of psychiatry in clinical practice
|June 17, 2025
概括
这项研究发现,自闭症症状严重程度在回归自闭症谱系障碍 (ASD-R) 和非回归自闭症谱系障碍 (ASD-NR) 之间没有显著差异. 然而,父母年龄在ASD-R组中更高.
科学领域:
- 儿童心理学 儿童心理学
- 神经发育障碍 神经发育障碍
- 儿科神经学 儿科神经学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 一部分患有自闭症的儿童表现出发育回归,这一现象尚未完全理解.
- 将回归性 (ASD-R) 和非回归性 (ASD-NR) 亚型进行比较对于理解潜在机制至关重要.
研究的目的:
- 为了比较土耳其儿童患有ASD-R和ASD-NR的临床特征,症状严重程度和产前/产周风险因素.
- 调查ASD发育回归的潜在预测因素.
主要方法:
- 对143名被诊断患有自闭症的儿童 (2-6岁) 进行了回顾性横截面研究.
- 参与者被分为ASD-R (n=29) 和ASD-NR (n=114) 组.
- 使用CARS,AuBC和ABC评估症状严重程度;收集了风险因素,和父母年龄的数据.
主要成果:
- 在ASD-R和ASD-NR组之间,整体症状严重程度 (CARS,AuBC,ABC总分) 没有显著差异.
- 在ASD-NR组显示较高的惰/社会退缩得分.
- 产前/产周风险因素和发病的患病率相似;父母出生时的年龄在ASD-R组显著更高.
- 后勤回归没有确定回归的显著预测因素.
结论:
- 产前和产周因素可能与影响ASD回归的遗传脆弱性相互作用.
- 需要进一步进行纵向研究,以阐明早期环境暴露和表观遗传机制在ASD回归模式中的作用.
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