果 (Mangifera indica L.) 种子的综合分析:植物化学特征,生物活性和营养潜力
Shafa Iman1, Mamoon Ur Rasheed2, Hamdy A Zahran3
1Department of Pharmacology, Faculty of Pharmaceutical Sciences Government College University Faisalabad Pakistan.
Food science & nutrition
|June 17, 2025
概括
果种子提取物 (MSE) 是一种安全,可持续的生物活性化合物的来源,具有显著的营养药和抗氧化剂潜力. 这项研究证实了其安全性和有效性,改善了脂质特征,并提供了对农业工业废物的环保价值化.
科学领域:
- 农业工业废弃物的价值化
- 营养药品和功能性食品.
- 植物化学分析和生物活性查
背景情况:
- 果种子是一种丰富的农业工业副产品,具有未被充分探索的生物活性潜力.
- 价值化果种子废弃物可以提供可持续的解决方案和新材料.
- 了解植物化学成分和生物活性对于应用开发至关重要.
研究的目的:
- 综合评估果种子提取物 (MSE) 的植物化学成分,营养特征,抗氧化活性,细胞毒性和安全性.
- 探索MSE作为生物活性化合物来源的潜力,用于营养药和功能性食品应用.
- 通过亚急性口服毒性和分子动态模拟来评估MSE的安全性和有效性.
主要方法:
- 营养分析 (大约组成,矿物质,氨基酸,维生素).
- 使用气体染色学-质谱学 (GC-MS) 进行植物化学分析.
- 在体外抗氧化剂测试 (DPPH,氧化激素清理).
- 对HepG2肝癌细胞的细胞毒性测定.
- 分子动态模拟 (MDS) 对于受体结合亲和力.
- 亚急性口服毒性测试和组织病理学检查.
主要成果:
- 丰富的蛋白质,油,碳水化合物和必需的矿物质 (K,Mg,P,Ca,Na).
- 确定的主要生物活性化合物包括提亚,酸和酸.
- MSE表现出强大的抗氧化活性和对HepG2细胞的剂量依赖性细胞毒性 (IC50 = 140μg/mL).
- MDS证实了 thiazole 与雌激素-β 和孕激素受体结合.
- 亚急性毒性测试显示,MSE是安全的,改善脂质概况 (↓胆固醇,LDL,甘油三,VLDL; ↑HDL) 和增加红细胞计数没有器官损伤.
结论:
- 果种子提取物 (MSE) 是一种安全和可持续的有价值的生物活性化合物的来源.
- MSE表现出显著的抗氧化剂,潜在的抗癌和降脂特性.
- 这些发现支持将果种子废弃物用于营养药,抗氧化剂和功能食品行业的价值化.
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