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使用胰岛素抵抗指数识别儿科MASLD

Kyungchul Song¹, Eunju Lee², Hye Sun Lee²

¹Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea.

JHEP reports : innovation in hepatology

|June 17, 2025

概括

胰岛素抵抗的代谢评分 (METS-IR) 和单点胰岛素敏感度估计器 (SPISE) 有效预测儿科代谢功能障碍相关的脂肪性肝病 (MASLD). 这些非侵入性标志物为早期检测和改善儿科MASLD的临床管理提供了有价值的工具.

科学领域:

儿科内分泌学儿科内分泌学
肝病学肝病学是一种肝病学.
代谢综合征研究代谢综合征研究

背景情况:

儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 正在增加,与心脏代谢风险有关.
有限的研究存在于有效的胰岛素抵抗标志物用于儿科MASLD预测.
早期检测对于管理儿科MASLD和相关并发症至关重要.

研究的目的:

调查甘油三和高血糖比率 (TG/HDL),甘油三和葡萄糖指数 (TyG),SPISE和METS-IR作为儿科MASLD的预测指标.
为了评估这些标记器的诊断性能,使用接收器操作特征 (ROC) 曲线.
确定用于早期检测和儿科MASLD的临床管理的非侵入性标志物.

主要方法:

使用NHANES (1,150名年轻人) 和现实世界诊所 (260名年轻人) 的数据进行横截面研究.
通过暂时弹性成像和腹部超声波评估的肝肥胖症.
进行了物流回归和ROC曲线分析,以评估MASLD的标志物可预测性.

主要成果:

与正常组相比,MASLD组的TG/HDL,TyG,METS-IR和肥胖率较高,SPISE较低.
在逻辑回归分析中,所有研究的标志物与MASLD有显著的相关性 (p <0.001).
与TG/HDL和TyG相比,SPISE和METS-IR在两个数据集中都显示出更高的预测性能 (更高的AUC).

结论:

METS-IR和SPISE是有效的,非侵入性的标志物,用于预测儿科MASLD.
这些标记物为儿童MASLD的早期识别和风险分层提供了有价值的工具.
验证的截止值在基于人口的和临床的环境中提供了实际的查应用.

关键词:

青少年是一个青少年.生物标志物生物标志物孩子孩子孩子孩子孩子孩子胰岛素耐药性胰岛素耐药性是一种与代谢功能障碍相关的脂肪性肝病.

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