接种COVID-19疫苗对月经不规则,出血模式和周期持续时间的影响:系统性审查和元分析
Ganesh Bushi1,2, Abhay M Gaidhane3, Nasir Vadia4
1Chitkara Centre for Research and Development Chitkara University Himachal Pradesh India.
Health science reports
|June 17, 2025
概括
接种COVID-19疫苗并没有显著增加月经干扰的风险. 虽然有些女性经历出血或周期长度的轻微变化,但对生殖健康的整体影响是最小的.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 人们担心COVID-19疫苗接种对妇女生殖健康的影响,特别是月经不规则.
- 这项研究探讨了月经干扰,出血模式和周期持续时间的潜在影响.
研究的目的:
- 系统地审查和元分析COVID-19疫苗接种对生殖年龄妇女月经健康的影响.
- 评估疫苗接种后的月经障碍,出血模式和周期持续时间的变化.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行系统搜索,截至2025年4月.
- 包括43项研究,其中747,763名年龄在13至50岁的妇女在接种疫苗后报告月经变化.
- 在R中进行的随机效应元分析,使用I2统计学来评估异质性.
主要成果:
- 在COVID-19疫苗接种和月经干扰增加之间没有发现显著的关联 (合并RR1.03,p=0.88).
- 接种疫苗后月经障碍的综合患病率为34%;观察到出血 (较轻/较重) 和周期长度 (较短/较长) 的轻微变化.
- 在分析中发现了高异质性 (I2=98%-100%),埃格尔测试表明了潜在的出版偏差.
结论:
- 接种COVID-19疫苗与月经干扰风险增加没有显著联系.
- 可能会发生轻微的月经周期变化,但对女性生殖健康的整体影响很小.
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