患者亲属的声音支持从机械通风中断奶:一个随机试验
Maximilian I Sprügel1, Marie-Louise Isenberg1, Jochen A Sembill1
1Universitätsklinikum Erlangen, Neurologische Klinik, 91054 Erlangen, Bayern, Germany.
亲属的音频录音有助于减少脑损伤患者的机械呼吸时间. 虽然没有显著减少断奶失败,但这种干预显示出治疗潜力和增加大脑活动.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 医疗技术 医疗技术 医学技术
背景情况:
- 从机械呼吸器中断患者,特别是那些严重脑损伤的患者,带来了重大挑战.
- 熟悉的听觉刺激,如声音和呼吸命令,可能会积极影响患者在断奶期间的结果.
研究的目的:
- 评估使用亲属录音的可行性,安全性和有效性,以帮助患者从机械通风中断奶.
主要方法:
- 一项随机化,假控制试验 (VOICE-WEANING II) 涉及患有神经疾病的成年患者,需要机械通风至少48小时.
- 干预组每天三次从亲属那里收到10分钟的音频录音;对照组收到了假 (沉默) 录音.
- 主要结果:断奶失败率. 二次结果:通风持续时间,气管切除术,妄想,死亡率和脑电图 (EEG) 评估的大脑活动.
主要成果:
- 在音频录音组 (52.4%) 和假控制组 (63.6%) 之间,断奶失败率没有显著差异.
- 干预组中观察到控制机械通风的持续时间显著减少 (调整后的差异-19.4小时;P = 0.03).
- 这种干预是可行的和安全的,在响应音频录音时,发现大脑活动增加,特别是在右前部中部区域.
结论:
- 亲属的录音并没有显著减少断奶失败,但确实缩短了机械通风的持续时间.
- 这些发现表明熟悉的声音在支持机械通风,断奶和改善大脑活动方面具有潜在的治疗效果.
- 需要进一步的研究来探索听觉干预在重症监护机构的治疗作用.
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