对LENT和PROMISE预后得分的外部验证,用于恶性多叶流血的预后得分
Craig A Mounsey1,2, Nikolaos I Kanellakis1,2,3, Dinesh N Addala1,3
1Oxford Pleural Unit, Oxford University Hospitals, Oxford, UK.
ERJ open research
|June 17, 2025
概括
LENT和PROMISE得分可以预测恶性多流的存活率,在3-12个月的存活预测中表现强. 需要进一步开发,以提高整体存活率估计的准确性.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 医学统计 医学统计
背景情况:
- 准确的生存估计对于管理恶性多叶流血 (MPE) 至关重要.
- LENT和PROMISE的分数旨在帮助MPE的预后,但其临床应用有限.
- 需要外部验证来评估这些预后得分的实用性和局限性.
研究的目的:
- 为了外部验证LENT和PROMISE对恶性多叶流液的得分.
- 评估这些分数在预测存活率方面的临床有用性.
- 识别限制得分表现的因素.
主要方法:
- 773名MPE患者的医疗记录 (2015-2023) 的回顾性审查.
- 在诊断时计算LENT和PROMISE得分.
- 使用歧视,校准和整体模型指标来预测3,6个月和12个月的生存率,评估得分表现.
主要成果:
- 无论是LENT和PROMISE分数都显示出对整体存活的预测能力,尽管中位数估计缺乏精度.
- 在预测3个月,6个月和12个月的存活率方面观察到更强的表现,C指数约为0.8和良好的校准.
- 局限的瘤类型分层和缺乏对敏感突变的考虑被确定为潜在的性能限制.
结论:
- "LENT"和"PROMISE"分数在恶性多流动中具有预后能力,因此应考虑对其进行临床使用.
- 确定了需要改善得分表现的领域,这些领域可以为未来的模型开发提供信息.
- 改进的模型可以提高MPE患者的预后准确性和临床决策.
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