在健康个体和克罗恩病患者中,默认模式网络连接和附着方式之间的差异关联
Alessandro Agostini1, Sara Ventura1, Silvia Tempia Valenta2
1Department of Clinical and Surgical Sciences, IRCCS S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
克罗恩病患者表现出改变的默认模式网络 (DMN) 连接,与依附不安全有关,与健康对照不同. 这些大脑差异可能会影响炎症性肠病 (IBD) 治疗中的自我认知和心理.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 克罗恩病 (CD) 与心理困扰和不安全的依恋方式有关.
- 之前的功能磁共振成像 (fMRI) 研究显示CD患者的大脑差异,但附着的神经相关性仍然不清楚.
研究的目的:
- 使用fMRI与健康对照 (HC) 相比,研究CD患者的附着维度的神经基础.
- 在CD中检查依恋方式和大脑连接之间的关系.
主要方法:
- 招募了19名CD患者和18名HC患者.
- 管理附着方式问卷 (ASQ) 来评估附着尺寸.
- 进行休息状态fMRI扫描来分析大脑连接.
主要成果:
- 附着得分在CD患者和HC患者之间是可比的.
- 健康对照组显示,默认模式网络 (DMN) 连接性降低,附加不安全性增加.
- 癌症患者表现出增加的DMN连接性与更高的附着不安全性,特别是在额头和带区域.
结论:
- 与依恋不安全相关的CD患者的DMN连接性改变可能表明自我监测和关系处理受损.
- 研究结果表明,依恋尺寸对于在炎症性肠道疾病 (IBD) 中管理心理压力是相关的.
- 强调了在IBD治疗中基于心态化的心理治疗干预的潜力.
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