22q11.2 删除综合征:认知,视觉运动和适应性功能沿纵跟踪
L Wallin1,2, C Gillberg1,3, J Knutsson1,3
1Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Brain and behavior
|June 17, 2025
概括
22q11.2删除综合征 (22q11.2DS) 成人的认知功能整体保持稳定,但女性的认知功能呈现下降. 长期监测对于个性化支持和管理精神病风险至关重要.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 心理学 心理学 心理学
背景情况:
- 有限的纵向数据存在于22q11.2删除综合征 (22q11.2DS) 的成年人的认知,视觉运动和适应功能.
- 对这一群体来说,了解长期结果至关重要.
研究的目的:
- 纵向评估22q11.2DS的成年人的认知,视觉运动和适应功能.
- 检查这些功能与长期结果之间的关系.
主要方法:
- 一组79名患有22q11.2DS的成年人 (随访时年龄为18-50岁) 在15年的中位数中被评估两次.
- 进行了临床,神经心理和适应性功能评估.
主要成果:
- 群体级全尺度智商系数 (FSIQ) 稳定,但女性的FSIQ和视觉运动整合率有所下降.
- 越来越多的参与者表现出不均的智商档案 (语言功能指数高于感知功能指数).
- 严重到中度的适应性障碍被注意到,基线FSIQ预测了以后的适应性功能.
结论:
- 尽管在组级稳定,但观察到个人认知能力下降.
- 长期跟踪对于个性化干预至关重要.
- 精神病子组中FSIQ和口头智商 (VIQ) 的下降可能表明或是精神病的结果.
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