环境和遗传对语言,认知,运动功能和社会行为的发展结果的影响
Marta Schiavon1, Birgitte K Burton1,2, Nicoline Hemager1,2,3,4
1CORE - Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
The European journal of neuroscience
|June 17, 2025
概括
环境因素在所有领域都对儿童神经发育产生重大影响. 遗传因素的关联较弱,主要与认知功能有关,这凸显了家庭环境的重要性.
科学领域:
- 发育神经科学的发展神经科学.
- 行为遗传学行为遗传学
背景情况:
- 儿童的神经发育受遗传和环境因素的影响.
- 这些因素之间的具体相互作用及其对各种神经发育领域的影响仍然不清楚.
研究的目的:
- 研究遗传和环境因素对儿童神经发育的不同和联合影响.
- 分析多基因评分对教育成绩 (PGS对EA) 和家庭观察对环境测量 (HOME) 与神经发育结果的关联.
主要方法:
- 对391名7岁儿童进行了回归分析.
- 分析了神经发育领域 (语言,运动,认知,社会行为) 和主要组件 (PC).
- 对EA (遗传代理) 和HOME (环境代理) 的PGS结果进行了回归.
主要成果:
- HOME与所有神经发育领域有着显著的关联.
- 对EA的PGS仅与认知功能名义上相关.
- PC1 (解释52.57%的差异) 与HOME相关,而PC2 (解释20.73%的差异) 与EA的PGS相关.
结论:
- 潜在的可改变的环境因素在多个领域的儿童神经发育中起着至关重要的作用.
- 与环境或遗传因素相关的确定直角维度,而不是两者兼而有之,为基因环境相互作用提供了洞察力.
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