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孕产妇高血压与口唇裂之间的关联:孟德尔的随机化研究

Wenkang Luan¹, Shujun Fan¹, Haojun Liang²

¹Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Current medicinal chemistry

|June 17, 2025

概括

孕产妇高血压与唇裂 (CL/P) 和唇裂 (CL) 的风险增加有关. 这项研究使用门德尔随机化来探索这种关联,发现对CL/P和CL有显著影响,但不仅有口腔裂口 (CPO).

科学领域:

遗传学遗传学是一个
流行病学流行病学
公共卫生公共卫生

背景情况:

唇裂 (CL/P) 的确切原因和危险因素尚未得到充分了解.
孕产妇高血压和CL/P之间的潜在因果关系需要进一步调查.

研究的目的:

调查孕产妇高血压对患口唇裂风险的潜在因果影响.
为了区分母高血压与特定的CL/P亚型 (CL/P,CL,CPO) 之间的关联.

主要方法:

使用两个样本的门德尔随机化 (MR) 分析.
用人全基因组协会研究 (GWAS) 的数据用于孕产妇高血压和CL/P.
应用了多种MR方法,包括反变量加权 (IVW) 和加权中位数,以及异质性和性测试.

主要成果:

孕产妇高血压与口唇裂 (CL/P) 的风险存在显著的因果关系 (IVW OR = 3.603,p = 0.024).
对于孕产妇的高血压,还确定了对裂唇 (CL) 风险的因果关系 (IVW OR = 5.968,p = 0.047).
在孕产妇高血压和Cleft Palate Only (CPO) 之间没有发现显著的因果关系.

结论:

孕产妇高血压与唇裂 (CL/P) 和唇裂 (CL) 的风险增加有关.
这些发现强调了在怀孕期间管理孕产妇高血压的重要性,以潜在地减少CL/P和CL的发生率.

关键词:

母亲高血压的高血压.门德尔的随机化嘴唇裂和 palatal palatal 裂是指口唇裂和 palatal 裂是指口唇裂和 palatal 裂是指口唇裂.全基因组关联研究研究.逆方差加权. 逆方差加权. 这是一个很好的方法.一个核酸的多态性.

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