肝细胞癌和TGF-β研究的全球趋势:从2000年到2024年的图书识别和可视化分析
Liu-Lin Yang1,2, Xing Chen2,3, Kai-Ting Huang1,2
1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Current protein & peptide science
|June 17, 2025
概括
本文献分析揭示了转化生长因子-β (TGF-β) 对肝细胞癌 (HCC) 研究的关键趋势. 最近的重点是代谢调节和免疫治疗,为未来的治疗策略提供了基础.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 转化生长因子-β (TGF-β) 通过影响免疫反应,炎症和上皮细胞-介质细胞过渡 (EMT) 来显著影响肝细胞癌 (HCC) 的进展.
- 由于其多方面的作用,TGF-β信号传递是高级HCC的关键治疗标.
研究的目的:
- 在2000年至2024年期间对TGF-β在HCC中的研究进行文献分析.
- 确定出版趋势,主要贡献者和新兴研究热点.
- 为未来对HCC中TGF-β的研究提供理论基础.
主要方法:
- 使用Web of Science核心集合 (WoSCC) 数据库用于出版数据.
- 分析了2000年1月1日至2024年10月16日的3026份出版物.
- 使用可视化工具 (CiteSpace,VOSviewer,SCImago Graphica) 来进行趋势和网络分析.
主要成果:
- 中国在出版量方面处于领先地位,富丹大学是最具生产力的机构.
- 肝病学发表了最多的文章,并产生了最高的引用影响.
- 最近的研究 (2020-2024) 强调了代谢调节,瘤免疫微环境以及TGF-β通路内的向疗法.
结论:
- 这项研究绘制了HCC中TGF-β的研究格局.
- 确定了关键趋势和有影响力的作品,以指导未来的研究方向.
- 提供了对TGF-β在HCC中的不断发展的理解和治疗向的见解.
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