检查长期服用含有β-基酸盐的饮料补充剂在患有2型糖尿病的成年人中的可行性:一项随机对照试点试验
Alexis Marcotte-Chénard1, Barbara Oliveira1, Juan Pablo Tortoriello1
1School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Journal of the American Nutrition Association
|June 17, 2025
概括
在2型糖尿病 (T2D) 中补充β-甲酸 (BHB) 显示出由于胃肠道问题和味道的混合可行性,但在试点试验中显示出潜在的降糖效应.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2D) 的管理仍然是一个重大的全球健康挑战.
- 外源补充剂是新兴的对代谢健康感兴趣的领域.
- 了解BHB补充剂在T2D中的可行性和有效性至关重要.
研究的目的:
- 评估长期,重复服用β-基酸盐 (BHB) 补充剂在患有T2D的成年人中的可行性.
- 评估BHB补充剂的招聘,合规性,学率和耐受性.
- 探索BHB补充剂在T2D中的潜在降糖效应.
主要方法:
- 一个90天,双盲,远程,随机,安慰剂控制的试验试验.
- 40名患有T2D的成年人被随机分配给含有BHB的补充剂或与味道匹配的安慰剂.
- 通过招聘,学,合规性,胃肠道症状和数据可用性评估可行性;进行探索性疗效分析.
主要成果:
- 大多数可行性标准都得到了满足,但BHB组的学率较高 (40%) 与安慰剂相比 (10%),主要是由于胃肠道症状和味道.
- 群体之间的遵守程度是相似的 (17-18饮料/周),但BHB组需要更多的努力来消费.
- 补充BHB显示了潜在的急性和慢性降糖效应,可接受性与胃肠道症状负相关.
结论:
- 远程试点试验显示,BHB补充剂在T2D中具有混合可行性.
- 在BHB组中,由于胃肠道问题和味道问题而导致的高退学率,尽管那些容忍它的人遵守了很好的标准.
- 证据表明降血糖的功效,表明个人可以容忍补充剂的潜力.
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