关于液体活检的最新情况
Marius E Mayerhoefer1,2, Andreas Kienzle3,4, Sungmin Woo1
1Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, 660 First Ave, New York, NY 10016.
Radiology
|June 17, 2025
概括
液体活检是一种使用血液或尿液的微创检测,可检测癌症标志物. 它对早期检测,治疗监测和预测各种癌症的结果充满希望.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 液体活检为检测体液中的瘤衍生物质提供了一种微创方法.
- 它是传统组织活检的经济有效替代品,特别是用于连续监测.
- 关键分析物包括无细胞和循环瘤DNA,这对于癌症管理至关重要.
研究的目的:
- 审查癌症检测和管理液体活检应用的最新进展.
- 突出临床试验和液体活检测试验的监管批准的发现.
- 讨论在瘤学中液体活检的临床实施挑战.
主要方法:
- 关于瘤学中的液体活检现有文献的综述.
- 对涉及液体活检的里程碑式临床试验的研究结果的分析.
- 检查美国监管机构对液体活检作为辅助诊断的批准.
主要成果:
- 液体活检检测瘤衍生分析物在小样本体积 (例如,10毫升血液/尿液) 中.
- 它在癌症查,残留疾病评估和结果预测方面显示出潜力.
- 与RECIST标准相比,液体活检可以提供较早的治疗反应检测.
结论:
- 液体活检是癌症患者全身瘤检查的宝贵工具.
- 它的应用特别在淋巴瘤,乳腺癌,前列腺癌和黑色素瘤中得到了注意.
- 解决当前的挑战对于液体活检在临床上得到广泛采用至关重要.
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