整个葡萄糖代谢连续性的心脏结构和功能
Tommi Grönlund1,2, Kari Kaikkonen1,2, M Juhani Junttila1,2
1Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Physiological reports
|June 17, 2025
概括
高血糖和糖尿病前期与健康成年人的心肌功能下降有关. 这一发现表明,即使没有被诊断为糖尿病,心力衰竭的潜在早期指标也存在.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病和糖尿病前期是已知的心力衰竭的危险因素.
- 糖化血红蛋白 (HbA1c) 对一般非糖尿病人群左心室缩功能的影响尚不清楚.
研究的目的:
- 在没有糖尿病或糖尿病前期的个体中,研究糖化血红蛋白 (HbA1c) 水平和全球纵向菌株 (GLS) 之间的关联.
- 在健康的中年人群中,评估心脏功能与不同HbA1c水平的关系.
主要方法:
- 利用心声回声学评估全球纵向应变 (GLS) 在636名健康的中年受试者从北芬兰出生队列1966年.
- 将参与者分为低,中,高正常HbA1c三分之一,以及糖尿病前期组进行比较分析.
- 采用对共变量调整的单变量分析来比较不同HbA1c组的心脏功能.
主要成果:
- 显著趋势 (p < 0.01) 的心肌收缩率下降,标志着异常的GLS,观察到增加HbA1c水平.
- 在高正常HbA1c组 (21.1%) 和糖尿病前组 (17.9%) 中,异常GLS的患病率明显高于低 (7.4%) 和中 (12.7%) 组.
- 在HbA1c水平和心脏结构变量之间没有发现任何关联.
结论:
- 在高正常范围内的HbA1c水平升高和糖尿病前期与健康中年个体的心肌收缩能力受损有关.
- 这些发现表明,高正常HbA1c和糖尿病前期可能是心力衰竭发展的早期预测因素.
- 需要进一步的研究来探索这些血糖状况对心血管的长期影响.
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