在患有膜心脏病的患者中预测膜置换后的逆重塑:一个纵向99米的Tc-FAPI SPECT/CT成像研究
1Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
概括
序列纤维细胞激活蛋白抑制剂 (FAPI) 成像可以监测膜心脏病 (VHD) 患者的门置换后的心肌逆向重塑. 较低的基线FAPI吸收率表明干预后完全逆向重塑的可能性更高.
科学领域:
- 心血管成像 - 心血管成像
- 分子成像学分子成像学
- 心脏纤维化是什么心脏纤维化
背景情况:
- 膜心脏病 (VHD) 中的纤维细胞激活有助于心肌重塑.
- 纤维细胞激活蛋白抑制剂 (FAPI) 成像可以识别这种激活.
- 监测反向改造门更换后的情况至关重要.
研究的目的:
- 探索系列FAPI成像用于监测VHD患者的门置换后心肌逆向重塑.
- 评估纤维细胞激活动态的可行性和定量跟踪.
主要方法:
- 31名VHD患者接受了99mTc-FAPI SPECT/CT和门置换前后心声扫描.
- 通过SUVmax,TBRmax和FAV量化FAPI吸收.
- 心声学评估左心室的几何参数进行重塑.
主要成果:
- FAPI吸收异质,但与大脑 natriuretic和LV质量指数的N端前激素相关.
- 重复的FAPI成像显示,干预后的TBRmax和FAV显著减少.
- 较低的基线TBRmax与完全逆转重塑有关.
结论:
- 系列99mTc-FAPI SPECT/CT可用于跟踪纤维细胞激活动态.门更换后.
- 程序前的FAPI成像可以预测完全逆向重塑的潜力.
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