对铁 (II) 的急性暴露会损害血管内皮的结构和功能
Anderson Ramiro Rangel Carnelli1, Maria Luiza Mageste Rosa1, Vinícius Giuseppe Rossi Baião Passamai1
1Laboratory of Cardiac Electromechanics and Vascular Reactivity, Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES, 29047-105, Brazil.
概括
急性铁中毒通过增加铁含量直接损害血管,导致功能和结构受损. 这项研究揭示了多余的铁如何通过活性氧物种影响血管度和氧化的可用性.
科学领域:
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 慢性铁过载与血管疾病有关.
- 急性过度铁对血管系统的直接影响尚不清楚.
研究的目的:
- 为了研究急性铁 (Fe2+) 暴露对大鼠动脉的影响.
- 为了确定反应性氧物种 (ROS) 是否调解这些血管效应.
主要方法:
- 鼠类大动脉细分的ex vivo化,含有不同度的FeSO4.
- 评估血管反应能力,ROS产量和内皮结构.
- 测量氧化 (NO) 的生物可用性.
主要成果:
- 2+暴露增加了收缩性血管活性和受损的内皮依赖血管扩张.
- 观察到NO的生物可用性降低,基和过氧化的产生增加.
- 微结构分析显示,在更高Fe2+度下,铁沉积和内皮细胞脱皮.
结论:
- 急性ex vivoFe2+暴露会导致度依赖的内皮损伤.
- 血管度受损的结果是NO生物可用性降低和ROS增加.
- 过量的铁对血管系统有直接的有害影响.
相关概念视频
01:28The Early Endosome: Endocytosis of Transferrin
3.4K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.4K
00:57The Periodic Table and Organismal Elements
184.9K
Overview
184.9K
01:24Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K