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乳腺摄影的化与晚期乳腺癌的风险有关

Karla Kerlikowske^1,2,3, Linn Abraham⁴, Brian L Sprague⁵

¹Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Karla.Kerlikowske@ucsf.edu.

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概括

乳房镜头结与更高的晚期乳腺癌风险有关,即使在女性有密集的乳房或更高的BMI. 这一发现强调了化作为侵袭性疾病的重要危险因素.

科学领域:

放射学和瘤成像学成像学
乳腺癌流行病学研究
风险评估模型风险评估模型

背景情况:

乳房图像化是查乳房图片的常见发现.
虽然与一般乳腺癌风险有关,但它们与晚期疾病的联系不太清楚.
识别晚期乳腺癌的新风险因素对于早期检测和干预至关重要.

研究的目的:

为了研究乳腺扫描化和晚期侵袭性乳腺癌的风险之间的联系.
为了确定化是否有助于晚期癌症风险,独立于其他已知的因素,如乳腺密度和体重指数 (BMI).

主要方法:

在乳腺癌监测联盟中,分析了来自991,991名女性 (40-74岁) 的超过370万张查性乳房造影.
累计5年晚期乳腺癌风险 (预后阶段≥II) 和危险比率 (HR) 的计算.
为更年期状态,乳腺密度和BMI (<25 kg/m2与≥25 kg/m2) 的调整.

主要成果:

在患有晚期乳腺癌的女性中,6.1%的女性存在化,而在其他女性中为3.6%.
结石与晚期癌症风险的关联在绝经前和绝经后的妇女中是相似的 (HR分别为1.4和1.5).
与没有化,乳房密或BMI升高的女性相比,乳房密,BMI≥25 kg/m2和化的绝经后妇女患晚期癌症的风险增加了5.5倍.

结论:

乳腺扫描结独立增加了晚期乳腺癌的风险,超出了密集的乳房和超重/肥胖所带来的风险.
需要进一步的研究来探索不同类型的化对风险的影响.
将化数据纳入风险模型可能会提高先进乳腺癌风险预测的准确性.

关键词:

晚期的癌症晚期的癌症乳腺癌的风险乳腺癌的风险乳房摄影的化成.

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