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Updated: Sep 19, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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单细胞和批量转录组分析识别了具有明显临床和分子特征的B细胞亚群和相关癌症亚型

Yin He1,2, Li Zhao3, Yufen Zheng4

  • 1Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Cellular oncology (Dordrecht, Netherlands)
|June 17, 2025
PubMed
概括

这项研究确定了八种不同的B细胞亚群及其在胰腺癌中的预后相关性. 这些发现提升了对B细胞异质性及其对癌症结果和免疫治疗反应的影响的理解.

关键词:
B细胞亚种群B细胞亚种群癌症预后和治疗反应癌症亚型的分类胰腺癌是一种癌症.预测模型的预测模型.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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