在荷兰增加了娱乐性胺的使用,随后爆发了泌尿系统并发症
Antoinette J H P van Riel1, Wouter M H van der Sanden2, Laetitia M O de Kort3
1Dutch Poisons Information Centre, University Medical Center Utrecht, Utrecht, The Netherlands.
Clinical toxicology (Philadelphia, Pa.)
|June 17, 2025
概括
荷兰的娱乐类胺使用量正在上升,导致胺诱导尿路病的显著增加. 这一趋势凸显了迫切需要提高用户和医疗保健提供者的意识,以防止公共卫生危机.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 在过去的几十年中,娱乐用胺的使用量在全球范围内有所增加.
- 这种增长与新出现的严重泌尿病并发症报告有关.
- 荷兰已经观察到与胺相关的健康问题日益增长的趋势.
研究的目的:
- 调查报告给荷兰毒素信息中心的急性胺中毒趋势.
- 探索胺诱导的尿路病变的发病率和特征,在专门的门诊诊所治疗.
- 分析胺使用模式和泌尿病并发症的发展之间的关联.
主要方法:
- 对2018年至2024年的数据进行了回顾性分析.
- 包括荷兰毒素信息中心对胺毒性的调查.
- 包括来自荷兰第一个专门的胺诱导性尿路病症门诊的患者数据.
主要成果:
- 胺中毒病例显著增加 (2018年为33例,到2024年为139例) 和胺诱导的尿路病例 (2018年为0例,到2024年为137例).
- 长期,大量使用胺类药物 (平均35个月每天高于1克) 与泌尿系统问题有关,主要在年轻男性中.
- 在中毒患者和尿路病患者中观察到高水平的其他物质 (酒精,药物) 的同时暴露;严重的病例需要手术干预,包括三名患者的囊切除术.
结论:
- 胺激素诱导的泌尿病症在荷兰是一个越来越严重的公共卫生问题.
- 通过毒素中心和医疗专家之间的合作来加强毒素监测至关重要.
- 提高休胺使用者和医疗保健专业人员的意识对于预防和早期干预至关重要.
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