合作和决策支持工具,以减轻尼尔马特雷尔维尔/里托纳维尔药物相互作用
Marsha L Pike1, Erin N Fischer, Sarah L Hirn
1Author Affiliations: Department of Nursing (Dr Pike, Ms Kriewall, and Ms Schmit), Clinical Informatics and Practice Support (Mss Fischer and Hirn), Registry, Research, and Oncology (Mr Kudrna), Division of Community Internal Medicine, Geriatrics, and Palliative Care (Dr Tulledge-Scheitel), and Department of Pharmacy (Dr Zhao), Mayo Clinic, Rochester, Minnesota.
一个新的协议安全地治疗了超过60%的高风险COVID-19患者,尽管药物相互作用,但使用nirmatrelvir/ritonavir (Paxlovid). 这种方法扩大了以前因药物冲突而被排除在外的人的获取.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 医疗保健服务研究 医疗服务研究
背景情况:
- 尼尔马特里尔维尔/里托纳维尔 (Paxlovid) 对高风险的COVID-19患者至关重要.
- 药物相互作用 (DDI) 限制了Paxlovid的使用,影响了疗效和安全性.
- 管理DDI对于扩大患者获得抗病毒治疗的机会至关重要.
研究的目的:
- 开发和实施护士发起的协议和专业间的指导,对nirmatrelvir/ritonavir的处方.
- 为了克服DDI的挑战,并加快对门诊,高风险的COVID-19患者的治疗.
- 使用标准化风险评分来指导治疗决策.
主要方法:
- 电子健康记录 (EHR) 决策支持工具的合作开发.
- 实施基于证据的DDI管理策略.
- 整合患者教育和跨专业团队支持.
主要成果:
- 在2020年11月至2023年2月期间,评估了3802名患有DDI的高风险患者.
- 成功治疗了2351名患者 (61.8%),否则将被排除在外.
- 证明了有效和安全的DDI管理策略.
结论:
- 实施的策略显著增加了涅马特雷尔维尔/里托纳维尔治疗率.
- 超过60%的DDI患者接受了治疗,克服了之前的排除标准.
- 这种方法为管理COVID-19治疗中的复杂药物相互作用提供了一个可扩展的模型.
相关概念视频
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Factors Affecting Protein-Drug Binding: Drug Interactions
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
Drug-Receptor Interactions
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Drug Therapy
Antianxiety Medications


